A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity

A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity

Abstract Background Clinical benefit from checkpoint inhibitors has been associated in a tumor-agnostic manner with two main tumor traits. The first is tumor antigenicity, which is typically measured by tumor mutation burden, microsatellite instability (MSI), or Mismatch Repair Deficiency using gene...

Full description

Bibliographic Details
Main Authors: Patrick Danaher, Sarah Warren, SuFey Ong, Nathan Elliott, Alessandra Cesano, Sean Ferree
Format: Article
Language:English
Published: BMJ Publishing Group 2019-01-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
MMRd
MSI
Biomarker
Diagnostic
Checkpoint inhibitors
TIS
Online Access:http://link.springer.com/article/10.1186/s40425-018-0472-1

Internet

http://link.springer.com/article/10.1186/s40425-018-0472-1

Similar Items