Transplantation of MHC-mismatched mouse embryonic stem cell-derived thymic epithelial progenitors and MHC-matched bone marrow prevents autoimmune diabetes

Transplantation of MHC-mismatched mouse embryonic stem cell-derived thymic epithelial progenitors and MHC-matched bone marrow prevents autoimmune diabetes

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for human T1D. Autoimmunity in NOD mice is associated with particular major his...

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Bibliographic Details
Main Authors: Min Su, Yujun Lin, Zhixu He, Laijun Lai
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Type 1 diabetes
Embryonic stem cells
Thymic epithelial cells
Autoreactive T cells
Regulatory T cells
Online Access:http://link.springer.com/article/10.1186/s13287-019-1347-1

Internet

http://link.springer.com/article/10.1186/s13287-019-1347-1

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