Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioav...

Full description

Bibliographic Details
Main Authors:	Kyeong-Ok Choi, Jaehyeog Choe, Seokjin Suh, Sanghoon Ko
Format:	Article
Language:	English
Published:	MDPI AG 2016-05-01
Series:	Molecules
Subjects:	poorly water soluble drug indomethacin nanostructured lipid nanocarrier N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride in vitro release
Online Access:	http://www.mdpi.com/1420-3049/21/5/672

Similar Items

Solubility, viscosity and rheological properties of water-soluble chitosan derivatives
by: Songwut Yotsawimonwat
Published: (2012-08-01)

Preparation and Characterization of Ultrasound Treated Polyvinyl Alcohol/Chitosan/DMC Antimicrobial Films
by: Rui Li, et al.
Published: (2019-09-01)

Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge of the Drug Delivery Systems
by: Angela Fabiano, et al.
Published: (2020-09-01)

Quaternized chitosan nanoparticles loaded with the combined attenuated live vaccine against Newcastle disease and infectious bronchitis elicit immune response in chicken after intranasal administration
by: Kai Zhao, et al.
Published: (2017-01-01)

Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin
by: Liang Hu, et al.
Published: (2014-08-01)

Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
by: Miller A Ruidiaz, et al.
Published: (2011-09-01)

Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
by: Shuai Yu, et al.
Published: (2021-04-01)

Kinetics and Thermodynamics Studies for Cadmium (II) Adsorption onto Functionalized Chitosan with Hexa-Decyl-Trimethyl-Ammonium Chloride
by: Cristina Ardean, et al.
Published: (2020-12-01)

Evaluation of Chitosan Derivatives Modified Mesoporous Silica Nanoparticles as Delivery Carrier
by: Qi Li, et al.
Published: (2021-04-01)

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens
by: Kai Zhao, et al.
Published: (2021-08-01)

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
by: Prakash Khadka, et al.
Published: (2014-12-01)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
by: Xingwang Zhang, et al.
Published: (2018-06-01)

Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
by: Malik A, et al.
Published: (2018-11-01)

Investigation on the sonocatalytic degradation of nitrobenzene using heterogeneous nanostructured catalysts in absence and presence of surfactant
by: F.Z. Yehia, et al.
Published: (2015-09-01)

Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles / Jacobus van Heerden
by: Van Heerden, Jacobus
Published: (2016)

Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles / Jacobus van Heerden
by: Van Heerden, Jacobus
Published: (2016)

REGULATION OF NITRATE REDUCTASE ACTIVITY IN RICE (ORYZA SATIVA L.) BY GROWTH REGULATORS
by: S HEMALATHA
Published: (2002-12-01)

WATER-SOLUBLE N -SUBSTITUTED CHITOSAN DERIVATIVES
by: Ph. Le Dung, et al.
Published: (2017-11-01)

<i>N</i>-2-Hydroxypropyl Trimethyl Ammonium Chloride Chitosan as Adjuvant Enhances the Immunogenicity of a VP2 Subunit Vaccine against Porcine <i>Parvovirus</i> Infection in Sows
by: Kai Zhao, et al.
Published: (2021-09-01)

Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo
by: Ziyue Xi, et al.
Published: (2020-02-01)

Novel PEG-Modified Hybrid PLGA-Vegetable Oils Nanostructured Carriers for Improving Performances of Indomethacin Delivery
by: Jana Ghitman, et al.
Published: (2018-05-01)

Evaluation of the Bactericidal and Fungicidal Activities of Poly([2-(methacryloyloxy)ethyl]trimethyl Ammonium Chloride)(Poly (METAC))-Based Materials
by: Toshiki Shiga, et al.
Published: (2018-08-01)

In Vivo Study of Entero- and Hepatotoxicity of Silver Nanoparticles Stabilized with Benzyldimethyl-[3-myristoylamine)-propyl]ammonium Chloride (Miramistin) to CBF1 Mice upon Enteral Administration
by: Yurii A. Krutyakov, et al.
Published: (2021-01-01)

LOCALLY MADE CHITOSAN COVALENTLY LINKED TO INDOMETHACIN: A NOVEL APPROACH TO FORMULATE SUSTAINED RELEASE INDOMETHACIN CAPSULE IN BASRAH
by: Akhlas F. Thajeel, et al.
Published: (2008-06-01)

Development of indomethacin sustained release microcapsules using chitosan-carboxymethylcellulose complex coacervation
by: Garnpimol C. Ritthidej, et al.
Published: (2003-05-01)

Nasal drug delivery of calcitonin with pheroid technology / Jeanéne Celesté Kotzé
by: Kotzé, Jeanéne Celesté
Published: (2009)

Nasal drug delivery of calcitonin with pheroid technology / Jeanéne Celesté Kotzé
by: Kotzé, Jeanéne Celesté
Published: (2009)

Formulation and processing technologies for dissolution enhancement of poorly water-soluble drugs
by: Hughey, Justin Roy
Published: (2013)

Investigation of Mechanistic Pathway for Trimethyl borate mediated Amidation of (R)-Mandelic Acid for the Synthesis of Mirabegron, an Antimuscarinic Agent
by: Vijayavitthal Thippannachar Mathad, et al.
Published: (2018-03-01)

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
by: Alexandra Teleki, et al.
Published: (2020-05-01)

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
by: Indumathi Sathisaran, et al.
Published: (2018-07-01)

Solubility Improvement by Solid Dispersion and Their Characterization: Indomethacin and Phenytoin
by: Sridhar, Vishak
Published: (2013)

Formation of particles prepared using chitosan and their trimethyl chitosan derivatives for oral vaccine delivery: Effect of molecular weight and degree of quaternization
by: Supavadee Boontha, et al.
Published: (2010-08-01)

Nasal delivery of insulin with Pheroid technology / Tanile de Bruyn
by: De Bruyn, Tanile
Published: (2009)

Nasal delivery of insulin with Pheroid technology / Tanile de Bruyn
by: De Bruyn, Tanile
Published: (2009)

Dissolution kinetics of ulexite prepared under different calcination temperatures
by: N. Demirk&#305;ran, et al.
Published: (2008-12-01)

Chitosan derived formulations and EmzaloidTM technology for mucosal vaccination against diphtheria : oral efficacy in mice / Elaine van der Westhuizen
by: Van der Westhuizen, Elaine
Published: (2009)

Chitosan derived formulations and EmzaloidTM technology for mucosal vaccination against diphtheria : oral efficacy in mice / Elaine van der Westhuizen
by: Van der Westhuizen, Elaine
Published: (2009)

Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs
by: Varaporn Buraphacheep Junyaprasert, et al.
Published: (2015-02-01)

Oral immunization of mice with Omp31-loaded N-trimethyl chitosan nanoparticles induces high protection against Brucella melitensis infection
by: Abkar M, et al.
Published: (2017-12-01)

Cannot write session to /tmp/vufind_sessions/sess_f58kclc3truj0pkgntegeid6b1