Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioav...

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Bibliographic Details
Main Authors: Kyeong-Ok Choi, Jaehyeog Choe, Seokjin Suh, Sanghoon Ko
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
poorly water soluble drug
indomethacin
nanostructured lipid nanocarrier
N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride
in vitro release
Online Access:http://www.mdpi.com/1420-3049/21/5/672

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http://www.mdpi.com/1420-3049/21/5/672

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