Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioav...

Full description

Bibliographic Details
Main Authors: Kyeong-Ok Choi, Jaehyeog Choe, Seokjin Suh, Sanghoon Ko
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
poorly water soluble drug
indomethacin
nanostructured lipid nanocarrier
N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride
in vitro release
Online Access:http://www.mdpi.com/1420-3049/21/5/672
id doaj-6badbf67f50549b9b86eee8f0c1996ba
record_format Article
spelling doaj-6badbf67f50549b9b86eee8f0c1996ba2020-11-24T23:54:19ZengMDPI AGMolecules1420-30492016-05-0121567210.3390/molecules21050672molecules21050672Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble DrugsKyeong-Ok Choi0Jaehyeog Choe1Seokjin Suh2Sanghoon Ko3Department of Food Science and Technology, Sejong University, 261 Neungdong-ro, Gwangjin-gu, Seoul 143-747, KoreaDepartment of Food Science and Technology, Sejong University, 261 Neungdong-ro, Gwangjin-gu, Seoul 143-747, KoreaDepartment of Food Science and Technology, Sejong University, 261 Neungdong-ro, Gwangjin-gu, Seoul 143-747, KoreaDepartment of Food Science and Technology, Sejong University, 261 Neungdong-ro, Gwangjin-gu, Seoul 143-747, KoreaThe objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoated one over the whole pH ranges and improved encapsulation efficiency. In vitro drug release showed that all NLC formulations showed higher in vitro release efficiency than drug particle at pH 7.4. Furthermore, NLC formulation prepared with chitosan or HTCC represented good sustained release property. The results indicate that chitosan and HTCC can be excellent formulating excipients of lipid-based delivery carrier for improving poorly water soluble drug delivery.http://www.mdpi.com/1420-3049/21/5/672poorly water soluble drugindomethacinnanostructured lipid nanocarrierN-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloridein vitro release
collection DOAJ
language English
format Article
sources DOAJ
author Kyeong-Ok Choi
Jaehyeog Choe
Seokjin Suh
Sanghoon Ko
spellingShingle Kyeong-Ok Choi
Jaehyeog Choe
Seokjin Suh
Sanghoon Ko
Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
Molecules
poorly water soluble drug
indomethacin
nanostructured lipid nanocarrier
N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride
in vitro release
author_facet Kyeong-Ok Choi
Jaehyeog Choe
Seokjin Suh
Sanghoon Ko
author_sort Kyeong-Ok Choi
title Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
title_short Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
title_full Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
title_fullStr Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
title_full_unstemmed Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
title_sort positively charged nanostructured lipid carriers and their effect on the dissolution of poorly soluble drugs
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2016-05-01
description The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoated one over the whole pH ranges and improved encapsulation efficiency. In vitro drug release showed that all NLC formulations showed higher in vitro release efficiency than drug particle at pH 7.4. Furthermore, NLC formulation prepared with chitosan or HTCC represented good sustained release property. The results indicate that chitosan and HTCC can be excellent formulating excipients of lipid-based delivery carrier for improving poorly water soluble drug delivery.
topic poorly water soluble drug
indomethacin
nanostructured lipid nanocarrier
N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride
in vitro release
url http://www.mdpi.com/1420-3049/21/5/672
work_keys_str_mv AT kyeongokchoi positivelychargednanostructuredlipidcarriersandtheireffectonthedissolutionofpoorlysolubledrugs
AT jaehyeogchoe positivelychargednanostructuredlipidcarriersandtheireffectonthedissolutionofpoorlysolubledrugs
AT seokjinsuh positivelychargednanostructuredlipidcarriersandtheireffectonthedissolutionofpoorlysolubledrugs
AT sanghoonko positivelychargednanostructuredlipidcarriersandtheireffectonthedissolutionofpoorlysolubledrugs
_version_ 1725466302063050752

Similar Items