2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways

2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways

Aims: To verify the effects of several 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) derivatives on LPS-induced NO production, cellular ROS levels and cytokine expression in BV-2 microglial cells. Main methods: An MTT assay and FACS flow cytometry were performed to assess the cellular viability and apopto...

Full description

Bibliographic Details
Main Authors: Hu-Nan Sun, Gui-Nan Shen, Yong-Zhe Jin, Yu Jin, Ying-Hao Han, Li Feng, Lei Liu, Mei-Hua Jin, Ying-Hua Luo, Tea-Ho Kwon, Yu-Dong Cui, Cheng-Hao Jin
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Heliyon
Subjects:
Neuroscience
Immunology
Cell biology
Medicine
Biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844016301657

Internet

http://www.sciencedirect.com/science/article/pii/S2405844016301657

Similar Items