Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse

Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse

Abstract Background Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8 wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum o...

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Bibliographic Details
Main Authors: Lauren N. Miterko, Joshua J. White, Tao Lin, Amanda M. Brown, Kevin J. O’Donovan, Roy V. Sillitoe
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Neural Development
Subjects:
Purkinje cell
Granule cell
Proliferation
Stem cells
Lobule
Ataxia
Online Access:http://link.springer.com/article/10.1186/s13064-019-0130-4

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http://link.springer.com/article/10.1186/s13064-019-0130-4

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