MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation

MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation

Abstract Background Cardiac arrest (CA) is associated with high morbidity and mortality, even after spontaneous circulation is re-established. This dire situation is partly due to post-CA syndrome for which no specific and effective intervention is available. One key component of post-CA syndrome is...

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Bibliographic Details
Main Authors: Maorong Jiang, Ran Li, Jingjun Lyu, Xuan Li, Wei Wang, Zhuoran Wang, Huaxin Sheng, Weiguo Zhang, Jörn Karhausen, Wei Yang
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Ischemia/reperfusion
NLRP3
Inflammasome
Sterile inflammation
Immunosuppression
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01933-y

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http://link.springer.com/article/10.1186/s12974-020-01933-y

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