Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes

Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes

Two new ultra-high performance liquid chromatography (UHPLC) methods for analyzing 21 selected antivirals and their metabolites were optimized, including sample preparation step, LC separation conditions, and tandem mass spectrometry detection. Micro-solid phase extraction in pipette tips was used t...

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Bibliographic Details
Main Authors: Luboš Fical, Maria Khalikova, Hana Kočová Vlčková, Ivona Lhotská, Zuzana Hadysová, Ivan Vokřál, Lukáš Červený, František Švec, Lucie Nováková
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
UHPLC-MS/MS
hydrophilic interaction chromatography
reversed phase
antiviral drug
microextraction
solid phase extraction
Online Access:https://www.mdpi.com/1420-3049/26/8/2123

Internet

https://www.mdpi.com/1420-3049/26/8/2123

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