Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity

Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity

Asymptomatic valproic acid (VPA)-induced hyperammonemia in the absence of liver impairment is fairly common. However, the underlying mechanisms through which VPA causes elevation in plasma ammonia (NH<sub>4</sub>) remains under investigation. Male Sprague Dawley rats (<i>n</i>...

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Bibliographic Details
Main Authors: Abdelnaser A. Badawy, Rasha Elghaba, Mohamed Soliman, Abdelaziz M. Hussein, Sana A. AlSadrah, Amira Awadalla, Osama A. Abulseoud
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Brain Sciences
Subjects:
valproic acid
ammonia
hyperammonemia
glutamine synthetase
striatum
prefrontal cortex
Online Access:https://www.mdpi.com/2076-3425/10/10/759

Internet

https://www.mdpi.com/2076-3425/10/10/759

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