Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1Ser616 Phosphorylation-Mediated Mitochondrial Fission

Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1Ser616 Phosphorylation-Mediated Mitochondrial Fission

Our previous studies showed that Astragaloside IV derivative (LS-102) exhibited potent protective function against ischemia reperfusion (I/R) injury, but little is known about the mechanisms. Mitochondrial fission regulated by dynamin-related protein1 (Drp1) is a newly recognized determinant of mito...

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Bibliographic Details
Main Authors: Li Chen, Xiao-Yi Chen, Qian-Long Wang, Si-Jin Yang, Hua Zhou, Li-Sheng Ding, Lin-Sen Qing, Pei Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
astragalosidic acid
myocardial ischemia reperfusion
mitochondrial fission
GSK-3β
Drp1 phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01083/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01083/full

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