Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts

Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts

The accumulation of senescent cells is implicated in the pathology of several age-related diseases. While the clearance of senescent cells has been suggested as a therapeutic target for patients with osteoarthritis (OA), cellular senescence of bone-resident osteoblasts (OB) remains poorly explored....

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Bibliographic Details
Main Authors: Maximilian G. Burger, Amir Steinitz, Jeroen Geurts, Benjamin E. Pippenger, Dirk J. Schaefer, Ivan Martin, Andrea Barbero, Karoliina Pelttari
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:International Journal of Molecular Sciences
Subjects:
osteoblast
osteoarthritis
oxidative stress
senescence
subchondral bone
transcriptomics
Online Access:https://www.mdpi.com/1422-0067/18/12/2517

Internet

https://www.mdpi.com/1422-0067/18/12/2517

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