Challenges in enumeration of CTCs in breast cancer using techniques independent of cytokeratin expression.

Given the current postulated plasticity between epithelial and mesenchymal states of migratory cancer cells the detection of non-epithelial CTCs is an important scientific and clinical goal.We used the filtration-based ISET technology to enrich circulating tumour cells (CTCs) in early breast cancer...

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Bibliographic Details
Main Authors: John Castle, Karen Morris, Susan Pritchard, Cliona C Kirwan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5397021?pdf=render