Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses

Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses

MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity of MVA vectors harboring the simultaneous deletion of A44L, related to steroid...

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Bibliographic Details
Main Authors: María Pía Holgado, Juliana Falivene, Cynthia Maeto, Micaela Amigo, María Fernanda Pascutti, María Belén Vecchione, Andrea Bruttomesso, Gabriela Calamante, María Paula del Médico-Zajac, María Magdalena Gherardi
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Viruses
Subjects:
MVA
vaccine
T-cell response
Online Access:http://www.mdpi.com/1999-4915/8/5/139

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http://www.mdpi.com/1999-4915/8/5/139

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