IRF4 and IRGs Delineate Clinically Relevant Gene Expression Signatures in Systemic Lupus Erythematosus and Rheumatoid Arthritis

IRF4 and IRGs Delineate Clinically Relevant Gene Expression Signatures in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Introduction: Overactivation of the type I interferon (IFN) signature has been observed in several systemic autoimmune conditions, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA). Impaired control of Interferon-Responding Genes (IRGs) expression by their regulatory mechanisms...

Full description

Bibliographic Details
Main Authors: Javier Rodríguez-Carrio, Patricia López, Mercedes Alperi-López, Luis Caminal-Montero, Francisco J. Ballina-García, Ana Suárez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
interferon
IFN signature
autoimmunity
systemic lupus erythematosus
arthritis
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03085/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03085/full

Similar Items