Big genomes facilitate the comparative identification of regulatory elements.

The identification of regulatory sequences in animal genomes remains a significant challenge. Comparative genomic methods that use patterns of evolutionary conservation to identify non-coding sequences with regulatory function have yielded many new vertebrate enhancers. However, these methods have n...

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Bibliographic Details
Main Authors: Brant K Peterson, Emily E Hare, Venky N Iyer, Steven Storage, Laura Conner, Daniel R Papaj, Rick Kurashima, Eric Jang, Michael B Eisen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2650094?pdf=render