Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes

Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes

The metabolic plasticity of cancer cells is considered a highly advantageous phenotype that is crucial for disease progression and acquisition of treatment resistance. A better understanding of cancer metabolism and its adaptability after treatments is vital to develop more effective therapies. To s...

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Bibliographic Details
Main Authors: Mans Broekgaarden, Anne-Laure Bulin, Jane Frederick, Zhiming Mai, Tayyaba Hasan
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Journal of Clinical Medicine
Subjects:
oncology
oxidative phosphorylation
metabolomics
reactive oxygen species
automated image analysis
two-photon excited fluorescence microscopy
Online Access:https://www.mdpi.com/2077-0383/8/9/1399

Internet

https://www.mdpi.com/2077-0383/8/9/1399

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