A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells

A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells

An endophytic fungus, Mycosphaerella nawae ZJLQ129, was isolated from the leaves of the traditional Chinese medicine Smilax china. From the fermentation broth and mycelium, a dibenzofurane compound (-)mycousnine (1) was isolated. Chemical modification of it to the amide derivative (-)mycousnine enam...

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Bibliographic Details
Main Authors: Li-Wei Wang, Jin-Liang Wang, Jing Chen, Jia-Jie Chen, Jia-Wei Shen, Xiao-Xiao Feng, Christian P. Kubicek, Fu-Cheng Lin, Chu-Long Zhang, Feng-Yang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Microbiology
Subjects:
Mycosphaerella nawae
(-)mycousnine enamine
dibenzofurane
T-cell targeting
immunosuppressive activity
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01251/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01251/full

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