Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca2+ into the cell. Here, we show t...
Main Authors: | A Catalina Vélez-Ortega, Mary J Freeman, Artur A Indzhykulian, Jonathan M Grossheim, Gregory I Frolenkov |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-03-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/24661 |
Similar Items
-
Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle
by: Itallia Pacentine, et al.
Published: (2020-01-01) -
The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells
by: Christopher L Cunningham, et al.
Published: (2017-05-01) -
The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing
by: Qing Fang, et al.
Published: (2015-08-01) -
Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function
by: Lucy A Dunbar, et al.
Published: (2019-09-01) -
TARGETING MECHANOTRANSDUCTION-RELATED GENES OF THE HAIR CELLUSING TALEN AND CRISPR/CAS TECHNOLOGY
by: Hu, Jiaqi
Published: (2015)