Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells

Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca2+ into the cell. Here, we show t...

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Bibliographic Details
Main Authors: A Catalina Vélez-Ortega, Mary J Freeman, Artur A Indzhykulian, Jonathan M Grossheim, Gregory I Frolenkov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/24661