Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist Entamoeba histolytica by Screening of Microbial Secondary Metabolites

Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist Entamoeba histolytica by Screening of Microbial Secondary Metabolites

Amebiasis is caused by infection with the protozoan parasite Entamoeba histolytica. Although metronidazole has been a drug of choice against amebiasis for decades, it shows side effects and low efficacy against asymptomatic cyst carriers. In addition, metronidazole resistance has been documented for...

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Bibliographic Details
Main Authors: Mihoko Mori, Satoshi Tsuge, Wataru Fukasawa, Ghulam Jeelani, Kumiko Nakada-Tsukui, Kenichi Nonaka, Atsuko Matsumoto, Satoshi Ōmura, Tomoyoshi Nozaki, Kazuro Shiomi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
amebiasis
antiamebic compounds
cysteine synthase
Entamoeba histolytica
microbial secondary metabolites
natural products
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00409/full

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00409/full

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