Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells

Summary: Accumulating evidence suggests that cancer cells with stem cell-like phenotypes drive disease progression and therapeutic resistance in glioblastoma (GBM). NOTCH regulates self-renewal and resistance to chemoradiotherapy in GBM stem cells. However, NOTCH-targeted γ-secretase inhibitors (GS...

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Bibliographic Details
Main Authors: Yufang Ma, Zhixiang Cheng, Jing Liu, Luke Torre-Healy, Justin D. Lathia, Ichiro Nakano, Yan Guo, Reid C. Thompson, Michael L. Freeman, Jialiang Wang
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304836

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http://www.sciencedirect.com/science/article/pii/S2213671117304836

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