Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC

Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC

Abstract Background The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate decision. The BAG1 protei...

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Bibliographic Details
Main Authors: Victoria J. Gennaro, Helen Wedegaertner, Steven B. McMahon
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
MYC
BAG1
HSP70
Apoptosis
Survival
Online Access:http://link.springer.com/article/10.1186/s12885-019-5454-2

Internet

http://link.springer.com/article/10.1186/s12885-019-5454-2

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