Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death

Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death

The identification of pathways necessary for retinal pigment epithelium (RPE) function is fundamental to uncover therapies for blindness. Prolactin (PRL) receptors are expressed in the retina, but nothing is known about the role of PRL in RPE. Using the adult RPE 19 (ARPE-19) human cell line and mou...

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Bibliographic Details
Main Authors: Rodrigo Meléndez García, David Arredondo Zamarripa, Edith Arnold, Xarubet Ruiz-Herrera, Ramsés Noguez Imm, German Baeza Cruz, Norma Adán, Nadine Binart, Juan Riesgo-Escovar, Vincent Goffin, Benito Ordaz, Fernando Peña-Ortega, Ataúlfo Martínez-Torres, Carmen Clapp, Stéphanie Thebault
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:EBioMedicine
Subjects:
Age-related retinal degeneration
Prolactin
Antioxidant
SIRT2
TRPM2 channels
Retinal pigment epithelium
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301359

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http://www.sciencedirect.com/science/article/pii/S2352396416301359

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