A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial.

Peptides delivered on the surface of influenza virosomes have been shown to induce solid humoral immune responses in experimental animals. High titers of peptide-specific antibodies were also induced in a phase 1a clinical trial in volunteers immunized with virosomal formulations of two peptides der...

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Main Authors: Shinji L Okitsu, Olivier Silvie, Nicole Westerfeld, Marija Curcic, Andreas R Kammer, Markus S Mueller, Robert W Sauerwein, John A Robinson, Blaise Genton, Dominique Mazier, Rinaldo Zurbriggen, Gerd Pluschke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2093993?pdf=render