Implicating calpain in tau-mediated toxicity in vivo.

Implicating calpain in tau-mediated toxicity in vivo.

Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in d...

Full description

Bibliographic Details
Main Authors: James B Reinecke, Sarah L DeVos, James P McGrath, Amanda M Shepard, Dustin K Goncharoff, Don N Tait, Samantha R Fleming, Michael P Vincent, Michelle L Steinhilb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3157467?pdf=render

Internet

http://europepmc.org/articles/PMC3157467?pdf=render

Similar Items