HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis

Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect. Whether genetically proxied HMGCR inhibition can reduce the risk of ankylosing spondylitis is unknown. We constructed an HMGCR genetic sc...

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Bibliographic Details
Main Authors: Zhenyu Zhong, Xiaojie Feng, Guannan Su, Liping Du, Weiting Liao, Shengyun Liu, Fuzhen Li, Xianbo Zuo, Peizeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HMGCR
ankylosing spondylitis
PCSK9
NPC1L1
genetic variant
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.731072/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.731072/full

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