Asymmetric synthesis of host-directed inhibitors of myxoviruses

Asymmetric synthesis of host-directed inhibitors of myxoviruses

High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development, we sought to increase both the potency and the a...

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Bibliographic Details
Main Authors: Terry W. Moore, Kasinath Sana, Dan Yan, Pahk Thepchatri, John M. Ndungu, Manohar T. Saindane, Mark A. Lockwood, Michael G. Natchus, Dennis C. Liotta, Richard K. Plemper, James P. Snyder, Aiming Sun
Format: Article
Language:English
Published: Beilstein-Institut 2013-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
asymmetric synthesis
benzimidazole
host-directed
myxovirus
small molecule inhibitor
Online Access:https://doi.org/10.3762/bjoc.9.23

Internet

https://doi.org/10.3762/bjoc.9.23

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