Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology

Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology

Background: This study was aimed to silencing the Nucleoside transporter 3 (NT3) permease nucleobases involved in the salvage pathway of Leishmania in order to disrupt purine nucleotide uptake in the parasite and consequently, destruction of the parasite. Methods: Overall, 502 bp fragment of the...

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Bibliographic Details
Main Authors: Farideh TOHIDI, Bahram KAZEMI, Mojgan BANDEHPOUR, Iraj SHARIFI, Mohammad Reza RABIEI, Ebrahim SAEDI DEZAKI, Zahra BABAEI
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2019-03-01
Series:Iranian Journal of Parasitology
Subjects:
Nucleoside transporter 3 gene
Leishmania major
Antisense RNA
Drug target
Gene expression
Online Access:http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1904

Internet

http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1904

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