Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]

The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP (dalcetrapib, torcetrapib, anacetrapib). In contrast with torcetrapib and anacetrapib, dalcetrapib requires cysteine 13 to decrease CETP activit...

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Bibliographic Details
Main Authors: Eric J. Niesor, Christine Magg, Naoto Ogawa, Hiroshi Okamoto, Elisabeth von der Mark, Hugues Matile, Georg Schmid, Roger G. Clerc, Evelyne Chaput, Denise Blum-Kaelin, Walter Huber, Ralf Thoma, Philippe Pflieger, Makoto Kakutani, Daisuke Takahashi, Gregor Dernick, Cyrille Maugeais
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Journal of Lipid Research
Subjects:
dalcetrapib
torcetrapib
anacetrapib
high density lipoprotein-functionality
apolipoproteins
bile acids and salts/metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520313559

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http://www.sciencedirect.com/science/article/pii/S0022227520313559

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