Inhibition of MMP-2 Expression with siRNA Increases Baseline Cardiomyocyte Contractility and Protects against Simulated Ischemic Reperfusion Injury

Inhibition of MMP-2 Expression with siRNA Increases Baseline Cardiomyocyte Contractility and Protects against Simulated Ischemic Reperfusion Injury

Matrix metalloproteinases (MMPs) significantly contribute to ischemia reperfusion (I/R) injury, namely, by the degradation of contractile proteins. However, due to the experimental models adopted and lack of isoform specificity of MMP inhibitors, the cellular source and identity of the MMP(s) involv...

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Bibliographic Details
Main Authors: Han-Bin Lin, Virgilio J. J. Cadete, Bikramjit Sra, Jolanta Sawicka, Zhicheng Chen, Lane K. Bekar, Francisco Cayabyab, Grzegorz Sawicki
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/810371

Internet

http://dx.doi.org/10.1155/2014/810371

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