Abnormal expression of GABAA receptor subunits and hypomotility upon loss of gabra1 in zebrafish

Abnormal expression of GABAA receptor subunits and hypomotility upon loss of gabra1 in zebrafish

We used whole-exome sequencing (WES) to determine the genetic etiology of a patient with a multi-system disorder characterized by a seizure phenotype. WES identified a heterozygous de novo missense mutation in the GABRA1 gene (c.875C>T). GABRA1 encodes the alpha subunit of the gamma-aminobutyric...

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Bibliographic Details
Main Authors: Nayeli G. Reyes-Nava, Hung-Chun Yu, Curtis R. Coughlin, Tamim H. Shaikh, Anita M. Quintana
Format: Article
Language:English
Published: The Company of Biologists 2020-04-01
Series:Biology Open
Subjects:
development
zebrafish
genetics
gabra1
locomotion
Online Access:http://bio.biologists.org/content/9/4/bio051367

Internet

http://bio.biologists.org/content/9/4/bio051367

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