pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated a...

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Bibliographic Details
Main Authors: Murtada A. Oshi, Juho Lee, Jihyun Kim, Nurhasni Hasan, Eunok Im, Yunjin Jung, Jin-Wook Yoo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
cyclosporine A
colon-targeted delivery
ionic gelation
microparticles
ulcerative colitis
Online Access:https://www.mdpi.com/1999-4923/13/9/1412

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https://www.mdpi.com/1999-4923/13/9/1412

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