Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis.

Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis.

Phosphoinositide-3-kinase (PI3K)/Akt dependent signaling has been shown to improve outcome in sepsis/septic shock. There is also ample evidence that PI3K/Akt dependent signaling plays a crucial role in maintaining normal cardiac function. We hypothesized that PI3K/Akt signaling may ameliorate septic...

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Bibliographic Details
Main Authors: Chuanfu Li, Fang Hua, Tuanzhu Ha, Krishna Singh, Chen Lu, John Kalbfleisch, Kevin F Breuel, Tiffany Ford, Race L Kao, Ming Gao, Tammy R Ozment, David L Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3446980?pdf=render

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http://europepmc.org/articles/PMC3446980?pdf=render

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