A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs

A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs

In this study, we explore the virulence of vesicular stomatitis New Jersey virus (VSNJV) in pigs and its potential relationship with the virus’s ability to modulate innate responses. For this purpose, we developed a mutant of the highly virulent strain NJ0612NME6, containing a single amino acid subs...

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Bibliographic Details
Main Authors: Lauro Velazquez-Salinas, Steven J. Pauszek, Lauren G. Holinka, Douglas P. Gladue, Steven I. Rekant, Elizabeth A. Bishop, Carolina Stenfeldt, Antonio Verdugo-Rodriguez, Manuel V. Borca, Jonathan Arzt, Luis L. Rodriguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Microbiology
Subjects:
vesicular stomatitis
pathogenesis
M51R
virulence
macrophages
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01123/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01123/full

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