Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior

Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior

Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking. The mammalian target of rapamycin signaling pathway is involved in reconsol...

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Bibliographic Details
Main Authors: Fushen Zhang, Shihao Huang, Haiyan Bu, Yu Zhou, Lixiang Chen, Ziliu Kang, Liangpei Chen, He Yan, Chang Yang, Jie Yan, Xiaohong Jian, Yixiao Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
mTOR
rapamycin
reconsolidation
drug memory
self-administration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.652865/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.652865/full

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