Cystatin-B Negatively Regulates the Malignant Characteristics of Oral Squamous Cell Carcinoma Possibly Via the Epithelium Proliferation/Differentiation Program

Cystatin-B Negatively Regulates the Malignant Characteristics of Oral Squamous Cell Carcinoma Possibly Via the Epithelium Proliferation/Differentiation Program

Disturbance in the proteolytic process is one of the malignant signs of tumors. Proteolysis is highly orchestrated by cysteine cathepsin and its inhibitors. Cystatin-B (CSTB) is a general cysteine cathepsin inhibitor that prevents cysteine cathepsin from leaking from lysosomes and causing inappropri...

Full description

Bibliographic Details
Main Authors: Tian-Tian Xu, Xiao-Wen Zeng, Xin-Hong Wang, Lu-Xi Yang, Gang Luo, Ting Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
oral squamous cell carcinoma
head and neck squamous cell carcinoma
cysteine cathepsin
cystatin-B
epithelial proliferation/differentiation
WGCNA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.707066/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.707066/full

Similar Items