Morphine-Induced Preconditioning: Involvement of Protein Kinase A and Mitochondrial Permeability Transition Pore.

Morphine-Induced Preconditioning: Involvement of Protein Kinase A and Mitochondrial Permeability Transition Pore.

BACKGROUND:Morphine induces myocardial preconditioning (M-PC) via activation of mitochondrial large conductance Ca2+-sensitive potassium (mKCa) channels. An upstream regulator of mKCa channels is protein kinase A (PKA). Furthermore, mKCa channel activation regulates mitochondrial bioenergetics and t...

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Bibliographic Details
Main Authors: Marianne Dorsch, Friederike Behmenburg, Miriam Raible, Dominic Blase, Hilbert Grievink, Markus W Hollmann, André Heinen, Ragnar Huhn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4788451?pdf=render

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http://europepmc.org/articles/PMC4788451?pdf=render

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