PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes

PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes

Summary: Cardiac metabolism is a high-oxygen-consuming process, showing a preference for long-chain fatty acid (LCFA) as the fuel source under physiological conditions. However, a metabolic switch (favoring glucose instead of LCFA) is commonly reported in ischemic or late-stage failing hearts. The m...

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Bibliographic Details
Main Authors: Aude Angelini, Pradip K. Saha, Antrix Jain, Sung Yun Jung, Randall L. Mynatt, Xinchun Pi, Liang Xie
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
cardiac metabolism switch
carnitine O-palmitoyltransferase 1b
myocardial infarction
heart failure
hypoxia
long-chain fatty acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012213

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721012213

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