All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo

All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo

Abstract Background Clustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) have recently opened a new avenue for gene therapy. Cas9 nuclease guided by a single-guide RNA (sgRNA) has been extensively used for genome editing. Currently, three Cas9 ort...

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Bibliographic Details
Main Authors: Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, Erik J. Sontheimer
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Biology
Subjects:
CRISPR
All-in-one rAAV
Genome editing
NmeCas9
Online Access:http://link.springer.com/article/10.1186/s13059-018-1515-0

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http://link.springer.com/article/10.1186/s13059-018-1515-0

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