Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, w...

Full description

Bibliographic Details
Main Authors: Noureldin Saleh, Gunnar Kleinau, Nicolas Heyder, Timothy Clark, Peter W. Hildebrand, Patrick Scheerer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
MC4R
melanocortin-4 receptor
melanocortin-receptors
ligand binding
ligand selectivity
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00560/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00560/full

Similar Items