Rous Sarcoma Virus Genomic RNA Dimerization Capability In Vitro Is Not a Prerequisite for Viral Infectivity

Rous Sarcoma Virus Genomic RNA Dimerization Capability In Vitro Is Not a Prerequisite for Viral Infectivity

Retroviruses package their full-length, dimeric genomic RNA (gRNA) via specific interactions between the Gag polyprotein and a “Ψ” packaging signal located in the gRNA 5′-UTR. Rous sarcoma virus (RSV) gRNA has a contiguous, well-defined Ψ element, that directs the packaging of heterologous RNAs effi...

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Bibliographic Details
Main Authors: Shuohui Liu, Rebecca Kaddis Maldonado, Tiffiny Rye-McCurdy, Christiana Binkley, Aissatou Bah, Eunice C. Chen, Breanna L. Rice, Leslie J. Parent, Karin Musier-Forsyth
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
Rous sarcoma virus (RSV)
retroviruses
Gag polyprotein
packaging signal (Ψ)
selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE)
RNA secondary structure
Online Access:https://www.mdpi.com/1999-4915/12/5/568

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https://www.mdpi.com/1999-4915/12/5/568

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