Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects

Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects

Here we describe a chemical biology approach for elucidating potential toxicity mechanisms for thrombosis-related side effects. This work takes advantage of a large chemical biology data set comprising the effects of known, well-characterized reference agents on the cell surface levels of tissue fac...

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Bibliographic Details
Main Authors: Ellen L. Berg, Mark A. Polokoff, Alison O'Mahony, Dat Nguyen, Xitong Li
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:International Journal of Molecular Sciences
Subjects:
thrombosis
toxicity
primary human cells
endothelial cells
inflammation
cholesterol
aryl hydrocarbon receptor
nutrient sensing
pathway
tissue factor
bacterial sensing
hypoxia
Online Access:http://www.mdpi.com/1422-0067/16/1/1008

Internet

http://www.mdpi.com/1422-0067/16/1/1008

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