Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).

Bibliographic Details
Main Authors: Hirokazu Yagi, Maho Yagi-Utsumi, Rena Honda, Yusaku Ohta, Taiki Saito, Miho Nishio, Satoshi Ninagawa, Kousuke Suzuki, Takahiro Anzai, Yukiko Kamiya, Kazuhiro Aoki, Mahito Nakanishi, Tadashi Satoh, Koichi Kato
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15192-1
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spelling doaj-6a9a9c7e4540417ea33a586114d70dc42021-05-11T08:08:00ZengNature Publishing GroupNature Communications2041-17232020-03-011111910.1038/s41467-020-15192-1Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptorHirokazu Yagi0Maho Yagi-Utsumi1Rena Honda2Yusaku Ohta3Taiki Saito4Miho Nishio5Satoshi Ninagawa6Kousuke Suzuki7Takahiro Anzai8Yukiko Kamiya9Kazuhiro Aoki10Mahito Nakanishi11Tadashi Satoh12Koichi Kato13Graduate School of Pharmaceutical Sciences, Nagoya City UniversityGraduate School of Pharmaceutical Sciences, Nagoya City UniversityGraduate School of Pharmaceutical Sciences, Nagoya City UniversityExploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural SciencesGraduate School of Pharmaceutical Sciences, Nagoya City UniversityGraduate School of Pharmaceutical Sciences, Nagoya City UniversityInstitute for Molecular Science, National Institutes of Natural SciencesGraduate School of Pharmaceutical Sciences, Nagoya City UniversityInstitute for Molecular Science, National Institutes of Natural SciencesInstitute for Molecular Science, National Institutes of Natural SciencesExploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural SciencesBiotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)Graduate School of Pharmaceutical Sciences, Nagoya City UniversityGraduate School of Pharmaceutical Sciences, Nagoya City UniversityThe secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).https://doi.org/10.1038/s41467-020-15192-1
collection DOAJ
language English
format Article
sources DOAJ
author Hirokazu Yagi
Maho Yagi-Utsumi
Rena Honda
Yusaku Ohta
Taiki Saito
Miho Nishio
Satoshi Ninagawa
Kousuke Suzuki
Takahiro Anzai
Yukiko Kamiya
Kazuhiro Aoki
Mahito Nakanishi
Tadashi Satoh
Koichi Kato
spellingShingle Hirokazu Yagi
Maho Yagi-Utsumi
Rena Honda
Yusaku Ohta
Taiki Saito
Miho Nishio
Satoshi Ninagawa
Kousuke Suzuki
Takahiro Anzai
Yukiko Kamiya
Kazuhiro Aoki
Mahito Nakanishi
Tadashi Satoh
Koichi Kato
Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
Nature Communications
author_facet Hirokazu Yagi
Maho Yagi-Utsumi
Rena Honda
Yusaku Ohta
Taiki Saito
Miho Nishio
Satoshi Ninagawa
Kousuke Suzuki
Takahiro Anzai
Yukiko Kamiya
Kazuhiro Aoki
Mahito Nakanishi
Tadashi Satoh
Koichi Kato
author_sort Hirokazu Yagi
title Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_short Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_full Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_fullStr Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_full_unstemmed Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_sort improved secretion of glycoproteins using an n-glycan-restricted passport sequence tag recognized by cargo receptor
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-03-01
description The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).
url https://doi.org/10.1038/s41467-020-15192-1
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