Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).

Bibliographic Details
Main Authors: Hirokazu Yagi, Maho Yagi-Utsumi, Rena Honda, Yusaku Ohta, Taiki Saito, Miho Nishio, Satoshi Ninagawa, Kousuke Suzuki, Takahiro Anzai, Yukiko Kamiya, Kazuhiro Aoki, Mahito Nakanishi, Tadashi Satoh, Koichi Kato
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15192-1

Internet

https://doi.org/10.1038/s41467-020-15192-1

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