Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).
Bibliographic Details
| Main Authors: |
Hirokazu Yagi,
Maho Yagi-Utsumi,
Rena Honda,
Yusaku Ohta,
Taiki Saito,
Miho Nishio,
Satoshi Ninagawa,
Kousuke Suzuki,
Takahiro Anzai,
Yukiko Kamiya,
Kazuhiro Aoki,
Mahito Nakanishi,
Tadashi Satoh,
Koichi Kato |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-15192-1
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