Echinocandin Resistance in Has Broad Implications for Membrane Lipid Perturbations That Influence Drug-Target Interactions
Echinocandin drugs target the fungal enzyme β-(1,3)-glucan synthase (GS), which is required for the synthesis of cell wall component β-(1,3)- d -glucan. They are first-line therapy for Candida infections but are increasingly used as second-line therapy for Aspergillus infections. Resistance to echin...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-12-01
|
| Series: | Microbiology Insights |
| Online Access: | https://doi.org/10.1177/1178636119897034 |