From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase

From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase

Omniligase-1 is a broadly applicable enzyme for peptide bond formation between an activated acyl donor peptide and a non-protected acyl acceptor peptide. The enzyme is derived from an earlier subtilisin variant called peptiligase by several rounds of protein engineering aimed at increasing synthetic...

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Bibliographic Details
Main Authors: Ana Toplak, Eduardo F. Teixeira de Oliveira, Marcel Schmidt, Henriëtte J. Rozeboom, Hein J. Wijma, Linda K.M. Meekels, Rowin de Visser, Dick B. Janssen, Timo Nuijens
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Enzyme catalysis
Chemo-Enzymatic Peptide Synthesis (CEPS)
Peptiligases
Omniligase-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021000532

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http://www.sciencedirect.com/science/article/pii/S2001037021000532

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