Circadian timekeeping is disturbed in rheumatoid arthritis at molecular level.

<h4>Introduction</h4>Patients with rheumatoid arthritis (RA) have disturbances in the hypothalamic-pituitary-adrenal (HPA) axis. These are reflected in altered circadian rhythm of circulating serum cortisol, melatonin and IL-6 levels and in chronic fatigue. We hypothesized that the molec...

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Bibliographic Details
Main Authors: Vesa-Petteri Kouri, Juri Olkkonen, Emilia Kaivosoja, Mari Ainola, Juuso Juhila, Iiris Hovatta, Yrjö T Konttinen, Jami Mandelin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23335987/?tool=EBI