Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus

Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus

Exposure of lupus-prone female NZBWF1 mice to respirable crystalline silica (cSiO2), a known human autoimmune trigger, initiates loss of tolerance, rapid progression of autoimmunity, and early onset of glomerulonephritis. We have previously demonstrated that dietary supplementation with the ω-3 poly...

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Bibliographic Details
Main Authors: Abby D. Benninghoff, Melissa A. Bates, Preeti S. Chauhan, Kathryn A. Wierenga, Kristen N. Gilley, Andrij Holian, Jack R. Harkema, James J. Pestka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
omega-3 polyunsaturated fatty acids
autoimmunity
nanostring
lung
kidney
systemic lupus erythematosus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02851/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02851/full

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